Makārem Shīrāzi widely used Ṭabāṭabāʾī's interpretive opinions in his work Tafsīr Nemūne, and in significant cases, he has examined his opinions with a critical point of view. In this study, which was carried out with library tools and descriptive-analytical method, firstly, the types of criticism of Makārem Shīrāzī in relation to Al-Mizan of Ṭabāṭabāʾī were extracted, and then the evaluation and diagnosis of their accuracy and correctness will done. The question of the present study is: in what cases and with what reasons did Makārem Shīrāzī criticize Ṭabāṭabāʾī's opinions and how much is the validity of his criticism. In this study, after expressing Makārem's critics on Ṭabāṭabāʾī's opinions, it is tried to measure the validity of these criticisms by using rational and traditional reasons, the opinions of famous commentators and other evidences. It is necessary to defend this hypothesis that, except in the few cases where critics' objections to Ṭabāṭabāʾī's opinions are valid, most of the criticisms do not have the necessary validity and have many weaknesses.